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Fibromyalgia Medications

Other Antidepressants
Some newer antidepressants raise levels of different chemicals in the brain, such as serotonin and norepinephrine. Some examples of these antidepressants that may be used to treat fibromyalgia include:


Benzodiazepines help some people with fibromyalgia by relaxing tense, painful muscles and stabilizing the erratic brain waves that can interfere with deep sleep. These medicines can also relieve the symptoms of restless legs syndrome (RLS), which is common among people with fibromyalgia. Restless legs syndrome is characterized by unpleasant sensations in the legs, as well as twitching, particularly at night.
Because of the potential for addiction, healthcare providers usually prescribe benzodiazepines only for people who have not responded to other therapies. Some examples of benzodiazepines used as fibromyalgia medications include:

Antiseizure Medicines

Antiseizure medications (also known as anticonvulsants or seizure medicines) are helpful in treating pain, particularly neuropathic pain. Many people with fibromyalgia have burning or electrical shock feelings in their hands and feet. Seizure medicines have been helpful in improving these symptoms.
Besides Lyrica (which is approved to treat fibromyalgia symptoms), examples of seizure medicines used off-label include:
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What Is Fibromyalgia?

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