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Precautions and Warnings With Fentanyl

Before using fentanyl, make sure your healthcare provider is aware of any other medical conditions you may have. You may not be able to use this medication if you have a history of breathing problems, substance abuse, or a head injury. Other safety precautions with fentanyl include understanding the warnings of abuse potential, the safety of using the medicine when pregnant or breastfeeding, and potential drug interactions.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®) if you have:
 
  • A history of drug or alcohol dependence or abuse
  • A history of breathing problems, asthma, chronic obstructive pulmonary disease (COPD), or any other lung disease
  • Paralytic ileus (a condition in which food does not move through the intestines as normal, leading to intestinal obstruction or blockage)
  • A head injury, brain tumor, or increased pressure around the brain
  • A history of strokes
  • A history of seizures
  • Problems urinating
  • Low blood pressure (hypotension)
  • Gallbladder or pancreas disease
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A slow heart rate or abnormal heart rhythm
  • Mental health conditions, such as depression or schizophrenia 
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
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