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Drug Interactions With Fentanyl

Taking certain medications with fentanyl may result in potentially dangerous complications. Some of these interactions can increase your risk for side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, amphetamines, and beta blockers are among the product that can lead to drug interactions with fentanyl. To avoid problems, tell your healthcare provider about all other medicines you take.

An Overview of Fentanyl Interactions

Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®) may react with many other medications. Some of the drugs that may lead to interactions with fentanyl include but are not limited to:
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Desmopressin (DDAVP®, Minirin®,Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:


  • Nasal decongestants, such as:


  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide and thiazide-like diuretics, such as:
Warning: 10 Hidden Sources of Lactose

Fentanyl Drug Information

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