Drug Interactions With Fentanyl

More Information on Drug Interactions With Fentanyl

The following sections explain in detail the potentially negative interactions that can occur when fentanyl is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using fentanyl could increase your risk for serious side effects, including extreme drowsiness, confusion, or breathing problems. You should not drink alcohol while using this medication.
 
Alvimopan
Fentanyl may increase the risk for serious alvimopan side effects. Do not take alvimopan if you have used fentanyl in the past seven days.
 
Amphetamines
Combining amphetamines with fentanyl may increase the pain-relieving effects of fentanyl. Your healthcare provider may choose to monitor your response if you take these drugs together. You might need a lower fentanyl dosage.
 
Beta Blockers
Combining fentanyl with a beta blocker may lower your heart rate and blood pressure to potentially unsafe levels. If you take these drugs together, your healthcare provider may need to monitor your blood pressure and heart rate more closely.
 
Calcium Channel Blockers
Combining fentanyl with certain calcium channel blockers may lower your heart rate and blood pressure to potentially unsafe levels. Your healthcare provider may need to monitor your blood pressure and heart rate more closely if you take these medications together.
 
CYP 3A4 Inducer Medications
The body breaks down fentanyl using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining fentanyl with one of these drugs may decrease the level of fentanyl in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure your pain is adequately controlled if you use fentanyl with a CYP 3A4 inducer.
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Fentanyl Drug Information

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