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Side Effects of Fentanyl Buccal Tablets

Common Side Effects

Fentanyl buccal tablets have been studied thoroughly in clinical trials. In these studies, the side effects that occurred in people who were taking this pain medication were carefully documented. In all of the studies, long-acting opioid narcotics were used in addition to fentanyl buccal tablets. Therefore, it can be difficult to know whether the side effects observed were due to fentanyl buccal tablets or the other opioid medication.
In clinical studies, the most common fentanyl buccal tablet side effects included:
  • Nausea -- in up to 29 percent of people
  • Vomiting -- up to 20 percent
  • Dizziness -- up to 19 percent
  • Tiredness (fatigue) -- up to 16 percent
  • Swelling of the legs, ankles, or feet (edema) -- up to 12 percent
  • Constipation -- up to 12 percent
  • Weakness -- up to 11 percent
  • Dehydration -- up to 11 percent
  • Headaches -- up to 10 percent
  • Shortness of breath -- up to 9 percent
  • Drowsiness -- up to 9 percent
  • Diarrhea -- up to 8 percent
  • Decreased appetite -- up to 8 percent
  • Coughing -- up to 7 percent
  • Confusion -- up to 7 percent
  • Weight loss -- up to 7 percent
  • Pneumonia -- up to 6 percent
  • Low blood potassium levels (hypokalemia) -- up to 6 percent
  • Pain, including joint and back pain -- up to 6 percent
  • Insomnia -- up to 6 percent.
Other side effects that occurred in at least 1 percent of people who were taking fentanyl buccal tablets in clinical trials included:
  • An increased heart rate
  • Abdominal (stomach) pain
  • Inflammation of the lining of the mouth or tongue
  • Dry mouth
  • Indigestion or heartburn
  • Difficulty swallowing
  • Fever
  • Chills
  • Chest pain
  • Yellowing of the whites of the eyes or skin (jaundice)
  • Infections, including urinary tract infections (UTIs), respiratory tract infections, and skin infections
  • Tooth abscess (an infection at the root of the tooth)
  • Falls
  • Compression fracture of the spine (when the spinal vertebrae are compressed and break)
  • Increases in blood sugar levels
  • Muscle pain
  • Neck and shoulder pain
  • Itching
  • Rash
  • Cold sweats
  • Increased or decreased blood pressure (hypertension or hypotension)
  • Anemia or other blood cell problems
  • Blood clot in the leg.
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Fentanyl Buccal Tablet Information

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