Drug Interactions With Fentanyl Buccal Tablets

Taking certain medications in combination with fentanyl buccal tablets may result in dangerous complications. Some of these drug interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and drowsiness. Alcohol, antidepressants, beta blockers, and antipsychotic medications are some of the substances that can lead to negative drug interactions with fentanyl buccal tablets.

An Overview of Fentanyl Buccal Tablet Interactions

Fentanyl buccal tablets (Fentora®) are a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This medicine may potentially interact with many other medications.
 
Some of the products that may lead to fentanyl buccal tablet interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Drug Interactions With Fentanyl Buccal Tablets Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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