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Drug Interactions With Fentanyl Buccal Tablets

CYP 3A4 Inhibitor Medications
The body breaks down fentanyl buccal tablets using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining fentanyl buccal tablets with one of these CYP 3A4 inhibitors may increase the level of fentanyl in your body, increasing your risk for serious side effects, including drowsiness, confusion, and breathing difficulty. Your healthcare provider may monitor you more closely for side effects if you take fentanyl buccal tablets with a CYP 3A4 inhibitor.
 
Desmopressin
Fentanyl buccal tablets can increase the risk for desmopressin side effects. Do not take fentanyl buccal tablets with desmopressin without first speaking with your healthcare provider.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl buccal tablets in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using fentanyl buccal tablets.
 
Medications That Cause Drowsiness
Fentanyl buccal tablets cause significant drowsiness. Taking other medications that cause drowsiness while using these tablets may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before taking fentanyl buccal tablets with other medications that can cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl buccal tablets with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use fentanyl buccal tablets if you have taken an MAOI within the past 14 days.
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Fentanyl Buccal Tablet Information

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