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Drug Interactions With Fentanyl Buccal Tablets

Drug Interactions With Fentanyl Buccal Tablets Explained

The following sections explain in detail the potentially negative reactions that can occur when fentanyl buccal tablets are combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while taking fentanyl buccal tablets could potentially increase your risk for serious side effects, including extreme drowsiness, confusion, or breathing problems. You should not drink alcohol while using this medication.
 
Alvimopan
Fentanyl buccal tablets may increase the risk of serious alvimopan side effects. Do not take alvimopan if you have taken fentanyl buccal tablets in the past seven days.
 
Amphetamines
Combining amphetamines with fentanyl buccal tablets may increase the pain-relieving effects of fentanyl buccal tablets. Your healthcare provider may choose to monitor your response to fentanyl buccal tablets if you take these medications together, and possibly decrease your dose of the tablets.
 
Beta Blockers
Taking fentanyl buccal tablets with a beta blocker may cause a decrease in your heart rate and blood pressure, potentially to unsafe levels. If you take these medications together, your healthcare provider may need to closely monitor your blood pressure and heart rate.
 
Calcium Channel Blockers
Taking fentanyl buccal tablets with certain calcium channel blockers may cause your heart rate and blood pressure to decrease, potentially to unsafe levels. Your healthcare provider may need to closely monitor your blood pressure and heart rate if you take these medications together.
 
CYP 3A4 Inducer Medications
The body breaks down fentanyl buccal tablets using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining fentanyl buccal tablets with one of these CYP 3A4 inducers may decrease the level of fentanyl in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure your pain is adequately controlled if you take fentanyl buccal tablets with a CYP 3A4 inducer.
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Fentanyl Buccal Tablet Information

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