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Drug Interactions With Etodolac Extended-Release

Certain drug interactions with etodolac extended-release can cause increased levels of the medicines in the blood or other serious side effects, such as bleeding, stomach ulcers, or kidney damage. Medications that may cause drug interactions with this medication include: cyclosporine, ACE inhibitors, other nonsteroidal anti-inflammatory drugs, and certain herbal or nutritional supplements.

Drug Interactions With Etodolac Extended-Release: An Introduction

Etodolac extended-release (Lodine® XL) has a number of medicines that it can potentially interact with. Some of these drug interactions can occur when the medication is taken with:
  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
Several herbal and nutritional supplements can also interact with etodolac extended-release and may increase the risk of bleeding. Examples of these include, but are not limited to:
Top Foods to Fight Inflammation

Etodolac Extended-Release Medicine

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