Drug Interactions With Etodolac Extended-Release: An Introduction
Etodolac extended-release (
Lodine® XL) has a number of medicines that it can potentially interact with. Some of these drug interactions can occur when the medication is taken with:
- Warfarin (Coumadin®, Jantoven®)
- Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil®, Motrin®), naproxen (Aleve®, Anaprox®, Naprosyn®, Naprelan®), diclofenac (Cataflam®, Voltaren®), indomethacin (Indocin®), nabumetone (Relafen®), oxaprozin (Daypro®), celecoxib (Celebrex®), meloxicam (Mobic®), and others
- Aspirin
- Lithium (Eskalith®, Lithane®, Lithonate®, Lithotabs®)
- Diuretics, such as torsemide (Demadex®), furosemide (Lasix®), and hydrochlorothiazide
- ACE inhibitors, such as lisinopril (Zestril®, Prinivil®), fosinopril (Monopril®), captopril (Capoten®), quinapril (Accupril®), benazepril (Lotensin®), enalapril (Vasotec®), and ramipril (Altace®)
- Methotrexate (Rheumatrex®, Trexall™)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Digoxin (Digitek®, Lanoxin®, Lanoxicap®)
- Phenylbutazone
- Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with
etodolac extended-release and may increase the risk of bleeding. Examples of these include, but are not limited to:
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners, such as warfarin, while taking etodolac extended-release, your body may metabolize them differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
