Drug Interactions With Etodolac Extended-Release

Certain drug interactions with etodolac extended-release can cause increased levels of the medicines in the blood or other serious side effects, such as bleeding, stomach ulcers, or kidney damage. Medications that may cause drug interactions with this medication include: cyclosporine, ACE inhibitors, other nonsteroidal anti-inflammatory drugs, and certain herbal or nutritional supplements.

 

Drug Interactions With Etodolac Extended-Release: An Introduction

Etodolac extended-release (Lodine® XL) has a number of medicines that it can potentially interact with. Some of these drug interactions can occur when the medication is taken with:
 

 

Several herbal and nutritional supplements can also interact with etodolac extended-release and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners, such as warfarin, while taking etodolac extended-release, your body may metabolize them differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;