Drug Interactions With Etodolac Extended-Release

Other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using these pain relievers with etodolac extended-release can increase the risk for bleeding. However, acetaminophen (Tylenol®) products can be safely used.
 
Aspirin
Aspirin and etodolac extended-release can be used together. However, studies have indicated that the chances are higher for developing stomach ulcers when these medicines are combined. For your particular situation, talk to your healthcare provider about using aspirin and etodolac extended-release together.
 
ACE Inhibitors (Accupril, Lotensin, Vasotec, Altace, Zestril, Prinivil, Monopril, Capoten)
Etodolac extended-release may inhibit the blood pressure-lowering effects of ACE Inhibitors. Your healthcare provider may need to adjust your dose of these drugs.
 
Diuretics (Torsemide [Demadex], Furosemide [Lasix], Hydrochlorothiazide)
Etodolac extended-release may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Taking etodolac extended-release and lithium together may increase the levels of lithium in your body by decreasing the removal of lithium by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
Methotrexate (Rheumatrex, Trexall)
If you are taking both methotrexate and etodolac extended-release, your healthcare provider may monitor you more closely and adjust your dose of these drugs.
 
Cyclosporine (Gengraf, Neoral, Sandimmune)
Taking etodolac extended-release and cyclosporine together may increase the chances for kidney damage. Your healthcare provider may monitor you more closely and may need to adjust your dose of these drugs.
(Drug Interactions With Etodolac Extended-Release Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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