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Dosing With Etodolac Extended-Release

For the treatment of juvenile rheumatoid arthritis, dosing with etodolac extended-release is determined by body weight and generally ranges from 400 mg once daily to 500 mg twice daily. The recommended dosage for those treating osteoarthritis and rheumatoid arthritis symptoms is 400 mg to 1000 mg given once daily. Keep in mind that it may take several weeks before the drug begins to work to its full potential.

Dosing With Etodolac Extended-Release: An Introduction

The dose of etodolac extended-release (Lodine® XL) that your healthcare provider prescribes will vary depending on a number of factors, including:
  • The medical condition you are being treated for
  • Your body weight
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is always the case, do not adjust your dosing with etodolac extended-release unless your healthcare provider specifically instructs you to do so.
Juvenile Rheumatoid Arthritis
For juvenile rheumatoid arthritis, the recommended dose is based on weight. The actual dosage that your healthcare provider recommends will range from etodolac extended-release 400 mg once a day to etodolac extended-release 500 mg twice a day.
Osteoarthritis and Rheumatoid Arthritis
For osteoarthritis or rheumatoid arthritis symptoms, the recommended dosing ranges from 400 mg to 1000 mg given once daily.
For people with osteoarthritis or rheumatoid arthritis, etodolac extended-release may take up to several weeks before it begins to work to its full potential.

General Information on Dosing With Etodolac Extended-Release

Some considerations for people taking etodolac extended-release include:
  • Your etodolac extended-release dosage should be taken with a glass of water. Taking it with milk or food may prevent an upset stomach.
  • Do not break, chew, or crush the etodolac extended-release tablets.
  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the chances of developing serious side effects.
  • Etodolac extended-release should be taken at the same time each day to maintain an even level of medicine in your blood.
  • For etodolac extended-release to work properly, you have to take it as prescribed. The drug will not work if you take it in a different way than your healthcare provider has prescribed.
  • If you do not take your etodolac extended-release as scheduled, take your next dose as soon as you remember. If it is close to the next scheduled dose, skip the missed one and continue with normal dosing. Do not double the dose at one time or take with other NSAIDs. It is okay to take it with acetaminophen (Tylenol®).
  • If you are unsure about anything related to etodolac extended-release or your etodolac extended-release dosage, please talk to your doctor, nurse, or pharmacist. Do not stop taking this drug without first discussing it with your healthcare provider.
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