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Duragesic Drug Interactions

CYP 3A4 Inhibitor Medications
The body breaks down Duragesic using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining Duragesic with one of these CYP 3A4 inhibitors may increase the level of Duragesic in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you combine Duragesic with a CYP 3A4 inhibitor.
 
Desmopressin
Duragesic can increase the risk for desmopressin side effects. Talk to your healthcare provider prior to taking these medications together.
 
Grapefruit Juice
Grapefruit juice may increase the amount of Duragesic in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using Duragesic.
 
Medications That Cause Drowsiness
Duragesic causes significant drowsiness. Taking other medications that cause drowsiness while using Duragesic may lead to serious side effects, such as extreme sedation, low blood pressure, confusion, and serious breathing problems. Check with your healthcare provider before using Duragesic with other medications that can cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining Duragesic with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use Duragesic if you have taken an MAOI within the past 14 days.
 
Octreotide
Combining octreotide with Duragesic may increase the pain-relieving effects of Duragesic. Your healthcare provider may monitor your pain response if you take these medications together. You might need a lower Duragesic dose.
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Duragesic Medication Information

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