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Warnings and Precautions With Diflunisal

Specific Warnings and Precautions With Diflunisal

Warnings and precautions to be aware of prior to taking diflunisal include the following:
 
  • Diflunisal can interact with some medications (see Drug Interactions With Diflunisal).
     
  • All NSAIDs, including diflunisal, have been reported to cause cardiovascular events, such as a heart attack or stroke, both of which can result in loss of life. People with cardiovascular disease or who have risk factors for the condition appear to be at greater risk. To decrease the chances of these problems occurring, you should take the smallest effective dose for the shortest period of time. Call 911 if you notice:
 
    • Chest pain
    • Shortness of breath
    • Weakness
    • Slurred speech.
 
  • All NSAIDs, including diflunisal, may cause high blood pressure or make it worse. Thus, diflunisal should be used with caution in people with known high blood pressure.
     
  • All NSAIDs, including diflunisal, may cause congestive heart failure or swelling. Contact your healthcare provider if you notice unexplained weight gain or swelling (see Dolobid and Weight Gain). The drug should be used with caution in people with heart failure.
     
  • All NSAIDs, including diflunisal, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines (called perforations). These problems can lead to serious complications or even loss of life. Therefore, extreme caution should be used if diflunisal is prescribed to people with a history of ulcers or gastrointestinal bleeding. To decrease the chances of these problems occurring, you should take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs of stomach ulcers or bleeding, including:
 
    • Stomach pain
    • Indigestion
    • Black, tarry stools
    • Vomiting blood.
 
  • People taking NSAIDs, including diflunisal, can suffer kidney damage. It is more common in the elderly and people with kidney disease, heart failure, or liver problems. It is also more common in those taking diuretics or ACE inhibitors.
     
  • People taking diflunisal can suffer liver damage. Contact your healthcare provider immediately if you notice:
 
    • Nausea
    • Tiredness
    • Lethargy
    • Itchy or yellowing skin
    • Abdominal pain
    • Flu-like symptoms.
 
  • NSAIDs, including diflunisal, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice:
 
    • Hives
    • Unexplained rash
    • Difficulty breathing
    • Swelling of the face and throat.
 
  • In rare cases, people taking diflunisal can develop a serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking diflunisal and call your healthcare provider.
     
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting diflunisal. Alcohol can affect the way the liver works, indirectly affecting the way diflunisal works.
     
  • NSAIDS have been known to cause an increase in liver enzymes. Therefore, you should have a blood test that looks at your liver function before starting diflunisal and then again 12 weeks after treatment has started.
     
  • Diflunisal has been known to cause anemia. Therefore, if you are taking the drug for an extended amount of time and show signs of anemia, talk to your healthcare provider.
     
  • Problems with vision have been reported in people taking diflunisal. If you notice any changes in your vision, such as blurry vision or changes in color vision, contact your healthcare provider.
     
  • You should not take diflunisal with any other NSAID, as this may increase your risk for any of the problems discussed in this article. Many NSAIDs are available without a prescription, so read labels carefully. Examples of NSAIDs include:
 
 
  • Diflunisal is a pregnancy Category C medicine, meaning that the drug could potentially cause harm to your unborn child. If you are pregnant, you should take diflunisal only if the benefit to you outweighs the risk to the fetus. Diflunisal is not recommended for women in the third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking diflunisal, contact your healthcare provider immediately (see Dolobid and Pregnancy for more information).
     
  • You should not take diflunisal while nursing. Therefore, if you are nursing and taking diflunisal, ask your healthcare provider whether to stop nursing or to stop taking diflunisal.
     
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