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Side Effects of Diflunisal

Common side effects of diflunisal include diarrhea, headache, and heartburn. Uncommon side effects include confusion, swelling, and a spinning sensation. Some diflunisal side effects are potentially life-threatening and should be reported to your healthcare provider immediately, such as blood in the urine or stools and red or purple spots on the skin. Most people, however, tolerate the drug without any problems.

Side Effects of Diflunisal: An Overview

As with any medicine, side effects are possible with diflunisal (Dolobid®); but not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
Several factors seem to affect the chances of developing side effects, including:
  • Your age
  • Your general health
  • The dose of diflunisal taken
  • Other medical conditions you may have
  • Current medicines you may be currently taking.
(This article covers many, but not all, of the possible side effects with diflunisal. Your healthcare provider can discuss a more complete list of diflunisal side effects with you.)

Serious Diflunisal Side Effects

The U.S. Food and Drug Administration (FDA) warns that people using NSAIDs (nonsteroidal anti-inflammatory drugs), including diflunisal, may be at higher risk for heart attack or stroke than those who do not take NSAIDs. This warning does not apply to those who take aspirin, however. This risk may be higher in people taking NSAIDs for a long time. These events can occur without warning and can lead to loss of life. Call 911 if you experience any of the following symptoms:
  • Chest pain
  • Shortness of breath
  • Weakness on one part of your body
  • Slurred speech.
Other possibly serious side effects of diflunisal include but are not limited to:
  • Allergic reactions, such as:
    • Swelling of the face or body
    • Blisters
    • Unexplained skin rash
    • Wheezing
    • Difficulty breathing
  • Stomach or intestinal problems, including:
    • Bleeding
    • Ulcers
    • A hole (known as a perforation)
  • Liver damage, which can cause:
    • Nausea
    • Fatigue
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Excessive tiredness
Because diflunisal can increase the risk of major or life-threatening bleeding, contact your healthcare provider immediately if you notice any unusual bleeding or have any of the following symptoms:
  • Bloody nose
  • Black, tarry stools
  • Blood in the urine or stools
  • Vomiting blood
  • Red or purple spots on the skin.
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Diflunisal (Dolobid)

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