Drug Interactions With Diflunisal

An understanding of drug interactions with diflunisal before taking it can ensure a safe treatment process. Drugs that can interact with diflunisal include lithium, warfarin, methotrexate, and antacids. Drug interactions with diflunisal can also increase your risk of liver or kidney damage, reduce the effectiveness of some drugs, and raise the levels of certain medications in your blood.

Diflunisal (Dolobid)

Drug Interactions With Diflunisal: An Overview

Diflunisal (Dolobid^®) can potentially interact with a number of medicines. Some of these drug interactions with diflunisal include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Motrin^®, Advil^®), naproxen (Naprosyn^®), naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), meloxicam (Mobic^®), etodolac (Lodine^®), ketoprofen, ketorolac (Toradol^®), and others
Aspirin
Acetaminophen (Tylenol^®)
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), and ramipril (Altace^®)
Angiotensin II receptor blockers (ARBs), including losartan (Cozaar^®), valsartan (Diovan^®), irbesartan (Avapro^®), telmisartan (Micardis^®), and candesartan (Atacand^®)
Methotrexate (Rheumatrex^®, Trexall^™)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and others
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Antacids.

Several herbal and nutritional supplements can also interact with diflunisal and may increase the risk of bleeding. Examples of these include but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Diflunisal Continued: Page 2)