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Drug Interactions With Diflunisal

Corticosteroids
Using corticosteroids with diflunisal can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Diflunisal may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
 
Digoxin
Diflunisal may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping diflunisal.
 
Diuretics
Combining diflunisal with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking diflunisal and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining diflunisal with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine diflunisal with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Diflunisal may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
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