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When and How Do I Take It?

General considerations for when and how to take diflunisal include the following:
  • Diflunisal comes in tablet form. It is generally taken two times a day (based on your healthcare provider's recommendation).


  • To avoid an upset stomach, take your diflunisal with food or milk.


  • Do not break, chew, or crush the tablets.


  • For the medicine to work properly, you have to take it as prescribed. It will not work if you stop taking it.


  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the chances of serious side effects occurring.

Dosing for Diflunisal

The dosage your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you are currently taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Diflunisal Dosing for more information.)

Side Effects of Diflunisal

(The side effects of diflunisal listed below are not a complete list of possible side effects. Your healthcare provider can discuss a more complete list with you.)
As with any medicine, side effects are possible with diflunisal. Yet not everyone who takes the drug will experience side effects. In fact, if side effects do occur, in many cases, they are minor, meaning that they require no treatment or are easily treated by you or your healthcare provider. Serious side effects are also possible, but they occur less frequently.
The most common side effects of diflunisal include:
Less common but serious side effects include:
These potentially serious side effects are shared by most NSAIDs and can lead to life-threatening complications or even loss of life.
(Click Side Effects of Diflunisal to learn more, including possibly serious side effects to look out for.)
8 Frequent Pain Syndromes

Diflunisal (Dolobid)

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