Drug interactions with diclofenac sodium may increase the risk of kidney damage, reduce the activity of diuretics, or make ACE inhibitors less effective, among other things. Drugs that diclofenac sodium can potentially interact with include diuretics, other nonsteroidal anti-inflammatory drugs, and some herbal supplements. If drug interactions with diclofenac sodium are a concern, your healthcare provider may adjust your dosage or monitor you more closely.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with diclofenac sodium and may increase the risk of bleeding. Examples of these include but are not limited to: