Drug Interactions With Diclofenac Sodium

Drugs that can potentially interfere with diclofenac sodium include diuretics, other nonsteroidal anti-inflammatory drugs, and some herbal supplements. These interactions may increase the risk of kidney damage, reduce the activity of diuretics, or make ACE inhibitors less effective, among other things. If diclofenac sodium drug interactions are a concern, your healthcare provider may adjust your dosage or monitor you more closely.

Diclofenac Sodium Interactions: An Introduction

Diclofenac sodium (Voltaren®, Voltaren®-XR) can potentially interact with a number of medicines. Some of the medications that may cause drug interactions with diclofenac sodium include:
 
 
  • Anticoagulant and antiplatelet drugs, such as:
     
    • Aspirin (Bayer® and others)
    • Cilostazol (Pletal®)
    • Clopidogrel (Plavix®)
    • Dipyridamole (Persantine®)
    • Eptifibatide (Integrilin®)
    • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
    • Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Lithium (Eskalith®, Lithobid®)
  • Methotrexate (Rheumatrex®).
      
Several herbal and nutritional supplements can also interact with diclofenac sodium and may increase the risk of bleeding. Examples of these include but are not limited to:
 

 

This article does not apply to diclofenac sodium gel (Voltaren® Gel and Solaraze®) or diclofenac sodium eye drops (Voltaren Ophthalmic®).

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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