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Drug Interactions With Diclofenac Sodium

CYP 2C9 Inhibitors
The liver breaks down (metabolizes) this medication using certain enzymes known as CYP 2C9 enzymes. Several other medications, known as CYP 2C9 inhibitors, slow down these enzymes, potentially causing diclofenac sodium to build up in the bloodstream, perhaps increasing the risk of side effects. Check with your healthcare provider before taking such medications together.
  
Digoxin
Diclofenac sodium may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping diclofenac sodium.
 
Diuretics
Combining diclofenac sodium with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking diclofenac sodium and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining diclofenac sodium with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine diclofenac sodium with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Diclofenac sodium may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
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