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Dosing With Diclofenac Sodium

Diclofenac Sodium Dose for Ankylosing Spondylitis

The recommended starting diclofenac sodium dosage for most people with ankylosing spondylitis is 25 mg, four times a day. If needed, another 25 mg may be taken at bedtime.

General Information on Dosing With Diclofenac Sodium

Considerations for people taking diclofenac sodium include the following:
  • It may take several weeks for the full effects of diclofenac sodium to be felt.
  • It is usually recommended to take NSAIDs (like diclofenac sodium) with food to help prevent stomach upset. However, food may cause this medication to work more slowly.
  • Diclofenac sodium should be swallowed whole. It should not be chewed, crushed, or broken in half.
  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the risk of serious diclofenac sodium side effects.


  • Diclofenac sodium should be taken at the same time each day to maintain an even level in your blood.
  • For the medication to work properly, you have to take it as prescribed. 


  • If you do not take your diclofenac sodium as scheduled, take your missed dose as soon as you remember. If it is close to the next scheduled dose, skip the missed one and continue with normal dosing. Do not take double the dose or combine your dose with other NSAIDs (nonsteroidal anti-inflammatory drugs). It is generally okay to take it with acetaminophen (Tylenol®), however.
  • If you are unsure about anything related to diclofenac sodium dosing, talk to your doctor, nurse, or pharmacist. 


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