Diclofenac Sodium Side Effects (Cont.)

Serious Diclofenac Sodium Side Effects

Serious side effects with diclofenac sodium are uncommon, but possible. The U.S. Food and Drug Administration (FDA) warns that people using NSAIDs, including diclofenac sodium, may be at higher risk for heart attack or stroke than those people who do not take NSAIDs. This warning does not apply to those who take aspirin, however. This risk may be higher in people who have been taking NSAIDs for a long time. These events can occur without warning and can lead to loss of life. Call 9-1-1 if you experience any of the following symptoms:
 
  • Chest pain
  • Shortness of breath
  • Weakness on one part of your body
  • Slurred speech.
     
Other possibly serious side effectswith diclofenac sodium include but are not limited to:
 
  • Allergic reactions, such as swelling of the face or body, blisters, unexplained skin rash, wheezing, or difficulty breathing
  • Stomach or intestinal problems, including bleeding, ulcers, or a hole (known as a perforation)
  • Liver damage, which can cause nausea, fatigue, yellowing of the skin or whites of the eyes, and excessive tiredness
  • Kidney problems, including kidney failure
  • Fluid retention or unexplained weight gain
  • Congestive heart failure
  • Sensation that the pill is stuck in your throat.
     
Because diclofenac sodium can increase the risk of major or life-threatening bleeding, contact your healthcare provider immediately if you notice any unusual bleeding or have any of the following symptoms:
 
  • Bloody nose
  • Black, tarry stools
  • Blood in the urine or stools
  • Vomiting blood
  • Red or purple spots on the skin.
     
(Diclofenac Sodium Side Effects Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;