Drug Interactions With Diclofenac Potassium

A few of the drugs that can potentially interact with diclofenac potassium include aspirin, lithium, diuretics, and ACE inhibitors. Drug interactions with diclofenac potassium can change how your body metabolizes the drugs, raise your risk of stomach ulcers, and make some drugs less effective, among other things. Also, taking diclofenac potassium along with other NSAIDs or certain herbal and nutritional supplements can increase your risk of bleeding.

Drug Interactions With Diclofenac Potassium: An Introduction

Diclofenac potassium (Cambia, Cataflam®, Zipsor) can potentially interact with a number of other medicines. Some of these diclofenac potassium drug interactions include:
 
 
  • Anticoagulant and antiplatelet drugs, such as:
     
    • Aspirin (Bayer® and others)
    • Cilostazol (Pletal®)
    • Clopidogrel (Plavix®)
    • Dipyridamole (Persantine®)
    • Eptifibatide (Integrilin®)
    • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
    • Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Lithium (Eskalith®, Lithobid®)
  • Methotrexate (Rheumatrex®).
      
Several herbal and nutritional supplements can also interact with diclofenac potassium and may increase the risk of bleeding. Examples of these include but are not limited to:
 

 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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