Drug Interactions With Diclofenac Potassium (Cont.)

More Detail About Diclofenac Potassium Interactions

 

Warfarin (Coumadin, Jantoven)
If you are taking blood thinners, such as warfarin, while taking diclofenac potassium, your body may metabolize them differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well you blood is clotting.
 
Other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using these pain relievers with diclofenac potassium can increase the risk of bleeding. However, acetaminophen (Tylenol®) products can be safely used.
 
Aspirin
Aspirin and diclofenac potassium can be used together. However, studies have indicated that the chances of developing stomach ulcers are higher when these medicines are combined. Be sure to talk with your healthcare provider before using aspirin with diclofenac potassium.
 
ACE Inhibitors (Accupril, Lotensin, Vasotec, Altace, Zestril, Prinivil, Monopril, Capoten)
Diclofenac potassium may inhibit the blood pressure-lowering effects of ACE Inhibitors. Your healthcare provider may need to adjust your dose of these drugs.
 
Diuretics (Torsemide [Demadex], Furosemide [Lasix], Hydrochlorothiazide)
Diclofenac potassium may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs.
 
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Taking diclofenac potassium and lithium together may increase the levels of lithium in your body by decreasing the removal of lithium by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
(Drug Interactions With Diclofenac Potassium Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;