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Drug Interactions With Diclofenac Potassium

More Detail About Diclofenac Potassium Interactions

The following sections explain in detail the potential interactions that can occur when diclofenac is combined with the drugs listed above.
 
ACE Inhibitors
Diclofenac potassium might reduce the effectiveness of ACE inhibitors for lowering blood pressure and may also increase the risk of kidney damage. If you take diclofenac potassium with an ACE inhibitor, your healthcare provider should monitor your blood pressure to watch for this interaction.
 
ARBs
Combining diclofenac potassium with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
 
Beta Blockers
Combining diclofenac potassium with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to diclofenac potassium in the digestive tract and delay its absorption into the body. To avoid this drug interaction, diclofenac potassium should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
 
Corticosteroids
Using corticosteroids with diclofenac potassium can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Diclofenac potassium may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
 
CYP 2C9 Inducers
The liver breaks down (metabolizes) this medication using certain enzymes known as CYP 2C9 enzymes. Several other medications, known as CYP 2C9 inducers, speed up these enzymes, potentially making diclofenac potassium less effective. Check with your healthcare provider before taking such medications together.
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