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Precautions and Warnings With Diclofenac/Misoprostol

Specific Diclofenac/Misoprostol Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Because of the risks associated with its use, diclofenac/misoprostol should only be used at the lowest dose that controls symptoms for the shortest amount of time.
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), including diclofenac/misoprostol, have been reported to cause potentially life-threatening cardiovascular problems, including a heart attack and stroke. People with cardiovascular disease or risk factors for it appear to have a higher risk for these problems. In addition, this risk may increase the longer you take the medication. Seek immediate medical attention if you experience any of the following symptoms:
 
    • Chest pain
    • Shortness of breath
    • Weakness
    • Difficulty talking.
 
  • NSAIDs, including diclofenac/misoprostol, increase the risk for stomach and intestinal problems, such as bleeding, ulcers, and/or holes (perforations). These problems can be serious, and could lead to hospitalization and death. Older adults have a higher risk for serious stomach or intestinal problems from diclofenac/misoprostol use. Contact your healthcare provider right away if you have any symptoms of stomach or intestinal ulcers or bleeding, such as:
 
    • Abdominal (stomach) pain
    • Black, tarry, or bloody stools
    • Vomiting blood.
 
 
  • This medication can cause fluid retention and swelling, and should be used with caution in people who already have fluid retention or heart failure. Let your healthcare provider know if you notice any unexplained weight gain or swelling of your arms, hands, legs, ankles, feet, or other body parts while taking diclofenac/misoprostol.
 
  • Diclofenac/misoprostol can cause kidney damage, especially if used for a long period of time. In general, people with severe kidney problems should not take diclofenac/misoprostol, or should be closely monitored during its use.
 
  • Diclofenac/misoprostol has been reported to cause liver damage in some people, especially in the first one to two months of beginning treatment. Your healthcare provider will monitor your liver function using a simple blood test. Contact your healthcare provider if you develop signs of liver disease, such as:
 
    • Nausea
    • Extreme tiredness
    • Itching
    • Pain in the upper-right area of the abdomen (stomach)
    • Flu-like symptoms
    • Yellowing of the skin or whites of the eyes (jaundice).
 
  • Like other NSAIDs, diclofenac/misoprostol can cause a potentially life-threatening skin reaction. Stop taking this medicine and contact your healthcare provider immediately if you develop any type of skin rash during treatment.
 
  • Some people who take this medicine may have an allergic reaction to it. Although an allergic reaction to diclofenac/misoprostol is rare, it can be life-threatening. Seek immediate medical care if you have swelling of the face or throat or difficulty breathing.
 
  • Anemia may occur with diclofenac/misoprostol use. Talk to your healthcare provider if you experience signs of anemia, such as:
 
    • Fatigue or lack of energy
    • Dizziness
    • Pale skin
    • Shortness of breath
    • A rapid or irregular heartbeat.
 
  • Do not share this medicine with anyone else, as it may not be the right medicine for his or her symptoms. Also, the drug can cause abortion, premature birth, or birth defects if taken by a pregnant woman.
 
 
  • Diclofenac/misoprostol is a pregnancy Category X medication. This means that it is quite dangerous for use during pregnancy. Women who are pregnant should not take this drug. Also, you will need to use an effective form of birth control throughout treatment (see Arthrotec and Pregnancy).
 
  • Diclofenac/misoprostol passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Arthrotec and Breastfeeding).
 
8 Frequent Pain Syndromes

Diclofenac/Misoprostol Information

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