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Drug Interactions With Diclofenac/Misoprostol

Certain antacids, diuretics, and cholesterol medications can cause problems when used in combination with diclofenac/misoprostol. Some of these drug interactions can interfere with the effectiveness of the medications or increase your risk for potentially serious side effects. To minimize any complications, make sure your healthcare provider has an up-to-date list of all medications, vitamins, and supplements you are taking.

An Overview of Diclofenac/Misoprostol Interactions

Diclofenac/misoprostol (Arthrotec®) can potentially react with a number of other medications. Some of the products that may lead to drug interactions with diclofenac/misoprostol include but are not limited to:
  • ACE inhibitors, such as:
  • Angiotensin II receptor blockers (ARBs), such as:
  • Certain antacids
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • CYP 2C9 inhibitors, such as:
  • Lithium (Eskalith®, Eskalith CR®, Lithobid®)
  • Medications that "thin" the blood (anticoagulant and antiplatelet drugs), such as:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Voriconazole (VFEND®).
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Diclofenac/Misoprostol Information

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