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Drug Interactions With Diclofenac/Misoprostol

Diuretics
Diclofenac/misoprostol can decrease the effectiveness of diuretics. Talk to your healthcare provider before taking these drugs together.
 
Lithium
Taking diclofenac/misoprostol and lithium together may increase the levels of lithium in your blood. Your healthcare provider may need to monitor you more closely and adjust your lithium dosage if you take these medicines together.
 
"Blood Thinners" and Other Similar Drugs
Combining diclofenac/misoprostol with anticoagulants, antiplatelet drugs, or other medications that increase the risk for bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not take these medicines together without first talking to your healthcare provider.
 
Methotrexate
Diclofenac sodium may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Oxytocin
Oxytocin is a medication used to stimulate labor by causing contractions. Diclofenac/misoprostol contains misoprostol (Cytotec®), a medicine that can also cause uterine contractions. Taking these drugs together may increase the effects of oxytocin on the uterus.
 
Pemetrexed
Diclofenac/misoprostol may increase pemetrexed blood levels, which could increase your risk for side effects. Your healthcare provider will monitor you more closely if you take these medicines together. If you have kidney disease, your healthcare provider may recommend you avoid taking diclofenac/misoprostol two to five days before, the day of, and two days after you receive pemetrexed.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with diclofenac/misoprostol may increase the risk of GI bleeding. Check with your healthcare provider before taking diclofenac/misoprostol with one of these drugs.
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Diclofenac/Misoprostol Information

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