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Drug Interactions With Diclofenac/Misoprostol

Corticosteroids
Taking diclofenac/misoprostol with a corticosteroid may increase your risk for gastrointestinal (GI) side effects, including potentially serious side effects such as GI bleeding. Your healthcare provider may monitor you more closely for signs of GI problems if you take these medicines together.
 
Cyclosporine
Cyclosporine may increase blood levels of diclofenac/misoprostol, potentially increasing the risk for side effects. Taking these medicines together may also increase the risk for kidney problems. Talk with your healthcare provider before taking diclofenac/misoprostol with cyclosporine.
 
CYP 2C9 Inducer Medications
The liver breaks down diclofenac/misoprostol using enzymes known as CYP 2C9 enzymes, and certain medications known as CYP 2C9 inducers can increase the activity of these enzymes. Thus, combining diclofenac/misoprostol with one of these drugs may decrease the level of diclofenac/misoprostol in your blood, potentially making it less effective. Talk to your healthcare provider before taking these medicines together.
 
CYP 2C9 Inhibitor Medications
The liver breaks down diclofenac/misoprostol using enzymes known as CYP 2C9 enzymes, and certain medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining diclofenac/misoprostol with one of these drugs may increase the level of diclofenac/misoprostol in your blood, potentially increasing your risk for side effects. You may need to be monitored more closely if you take these medications together.
 
Digoxin
Diclofenac/misoprostol can increase the level of digoxin in the blood, possibly increasing your risk for potentially serious digoxin side effects. Your healthcare provider may need to check your digoxin blood level if you start or stop taking diclofenac/misoprostol.
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Diclofenac/Misoprostol Information

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