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Diclofenac/Misoprostol Dosage
Before you start taking diclofenac/misoprostol, your dosage will be determined based on the specific reason you are using this drug, other medications you are taking, and other factors. In general, diclofenac/misoprostol tablets are taken two to four times daily. You should take the tablets with a meal, and try to take your doses at the same times every day.
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The dose of diclofenac/misoprostol (Arthrotec®) your healthcare provider recommends may vary, depending on a number of factors, including:
- The reason you are taking the medication
- How well you tolerate it
- Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The standard diclofenac/misoprostol dosage for the treatment of osteoarthritis is diclofenac/misoprostol 50/200 three times a day. If you experience bothersome side effects, your healthcare provider may recommend you take diclofenac/misoprostol 50/200 or 75/200 twice a day. While twice-a-day dosing is generally well tolerated, it is also less effective at preventing ulcers.
In some cases, your healthcare provider may recommend that you take more misoprostol (Cytotec®) or diclofenac sodium (Voltaren®, Voltaren®-XR) -- the active ingredients in this drug -- in addition to diclofenac/misoprostol. If so, it is generally recommended that your total diclofenac dosage not exceed 150 mg a day when used to treat the symptoms of osteoarthritis. Misoprostol doses should generally not exceed 200 mg per dose or 800 mg per day.
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD