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Demerol Drug Interactions

A number of medications may interact with Demerol. Problems may occur if the pain reliever is taken together with protease inhibitors, triptans, or cimetidine, among other medications. These drug interactions could decrease the metabolism of Demerol into normeperidine (the toxic metabolite of the medicine), increase the risk of side effects, or cause a group of symptoms called serotonin syndrome.

Demerol Drug Interactions: An Overview

Demerol® (meperidine hydrochloride) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with Demerol include (but are not limited to):



  • Monoamine oxidase inhibitors (MAOIs), including:






8 Frequent Pain Syndromes

Demerol Drug Information

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