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Demerol Drug Interactions

Phenytoin
Phenytoin may increase the metabolism of Demerol into normeperidine (the toxic metabolite). This may decrease the effectiveness of Demerol while increasing the risk of dangerous side effects. Check with your healthcare provider before taking phenytoin and Demerol together.
 
Protease Inhibitors
Protease inhibitors may increase the metabolism of Demerol into normeperidine (the toxic metabolite). This may decrease the effectiveness of Demerol while increasing the risk of dangerous side effects. Check with your healthcare provider before taking Demerol with a protease inhibitor.
 
Sibutramine
Taking Demerol with sibutramine can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
St. John's Wort
Taking Demerol with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking Demerol with tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Triptans
Taking Demerol with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
8 Frequent Pain Syndromes

Demerol Drug Information

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