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Demerol Drug Interactions

Demerol Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Demerol is combined with any of the drugs listed above.
 
Acyclovir
Acyclovir may increase the level of Demerol and normeperidine (the toxic metabolite of Demerol) in the blood. This may increase the risk of serious Demerol side effects. Check with your healthcare provider before taking acyclovir with Demerol.
 
Cimetidine
Cimetidine may decrease the metabolism of Demerol into normeperidine. It is not clear how exactly this might affect the effectiveness or toxicity of Demerol. Check with your healthcare provider before taking Demerol with cimetidine, including non-prescription cimetidine products.
 
Linezolid
Taking Demerol with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucination, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Medications That Cause Drowsiness
Combining Demerol with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Demerol with such medications.
 
Additionally, combining Demerol with antidepressants may increase the risk of serotonin syndrome.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining Demerol with an MAOI can cause life-threatening reactions. Do not use Demerol and an MAOI within 14 days of each other.
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Demerol Drug Information

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