In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
Darvocet® (propoxyphene/acetaminophen) is a narcotic medication often used for relieving mild-to-moderate pain. It is available by prescription only and comes in tablet form.
Darvocet tablets are available in the following strengths:
- Darvocet-N 50 -- 50 mg of propoxyphene napsylate and 325 mg of acetaminophen
- Darvocet-N 100 -- 100 mg of propoxyphene napsylate and 650 mg of acetaminophen
- Darvocet A500 -- 100 mg of propoxyphene napsylate and 500 mg of acetaminophen.
For Darvocet-N 50 and Darvocet-N 100, the recommended dosage is 100 mg of propoxyphene napsylate and 650 mg of acetaminophen (equal to one Darvocet-N 100 tablet or two Darvocet-N 50 tablets). The recommended dose for Darvocet A500 is 100 mg of propoxyphene napsylate and 600 mg of acetaminophen (one Darvocet A500 tablet). The medicine is generally taken every four hours as needed for pain.
For Darvocet-N 100 and Darvocet A500, the maximum recommended dosage is six tablets per day. For Darvocet-N 50, the maximum recommended dosage is 12 tablets per day. If your kidney or liver function is not optimal, your healthcare provider may decide to prescribe a lower Darvocet dose.
(Click Darvocet Dosage for more detailed information on when and how to take Darvocet tablets and to find out what your healthcare provider may consider before making a dosing recommendation.)