Drug Interactions With Cyclobenzaprine

Meperidine
Combining meperidine and cyclobenzaprine may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Do not take cyclobenzaprine and a MAOI together (or within two weeks of each other), as combining these medications can cause life-threatening problems.
 
Narcotics or Opiates
Combining an opiate or narcotic with cyclobenzaprine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking cyclobenzaprine with an opiate or narcotic.
 
Sleep Medications
Combining a sleep medication with cyclobenzaprine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking cyclobenzaprine with a sleep medication.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
In general, it is not recommended to take cyclobenzaprine and tramadol together, as this may increase your risk of seizures. In addition, this combination may also increase the risk of serotonin syndrome.
 
Verapamil
Taking verapamil and cyclobenzaprine together may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 

Final Thoughts on Drug Interactions With Cyclobenzaprine

It is possible that not all cyclobenzaprine drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with cyclobenzaprine that may apply to you.
 
 
Alternative Therapies for Pain Management

Cyclobenzaprine Hydrochloride (HCl) Information

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