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Drug Interactions With Cyclobenzaprine

Certain Antidepressants or Fibromyalgia Medications
Taking cyclobenzaprine with certain depression or fibromyalgia medications can cause a group of symptoms called serotonin syndrome. These symptoms include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Meperidine
Combining meperidine and cyclobenzaprine may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Do not take cyclobenzaprine and a MAOI together (or within two weeks of each other), as combining these medications can cause life-threatening problems.
 
Narcotics or Opiates
Combining an opiate or narcotic with cyclobenzaprine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking cyclobenzaprine with an opiate or narcotic.
 
Sleep Medications
Combining a sleep medication with cyclobenzaprine can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking cyclobenzaprine with a sleep medication.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
In general, it is not recommended to take cyclobenzaprine and tramadol together, as this may increase your risk of seizures. In addition, this combination may also increase the risk of serotonin syndrome.
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