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Drug Interactions With Cyclobenzaprine ER

Certain medications may cause drug interactions with cyclobenzaprine ER, including narcotics, anticholinergics, benzodiazepines, and MAOIs. Combining these drugs with cyclobenzaprine ER can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. To help minimize your risk of developing cyclobenzaprine ER interactions, be sure to tell your healthcare provider about all other medications you are taking.

An Overview of Cyclobenzaprine ER Drug Interactions

Cyclobenzaprine ER (Amrix®) can potentially interact with several other medications. Some of these medicines that may lead to cyclobenzaprine ER drug interactions include:
  • Alcoholic beverages
  • Anticholinergics, including (but not limited to):



  • Barbiturate medications, such as:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, including:







Warning: 10 Hidden Sources of Lactose

Cyclobenzaprine ER Medication Info

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