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ConZip Warnings and Precautions

People who are using ConZip for pain relief should be aware that this medication can cause serious complications, such as seizures and potentially life-threatening breathing problems. Other safety precautions with ConZip involve warnings about using this drug while pregnant or breastfeeding. In addition, it can cause potentially serious reactions with alcohol and a number of medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking ConZip™ (tramadol ER) if you have:
  • Seizures or epilepsy
  • A history of drug or alcohol dependence
  • Suicidal thoughts or behaviors
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A head injury or high intracranial pressure
  • Severe abdominal (stomach) pain
  • Lung disease of any sort
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With ConZip

Some warnings and precautions to be aware of prior to using this pain medicine include the following:
  • ConZip may increase the risk of seizures, especially in people who:
    • Have a history of seizures
    • Are withdrawing from alcohol or narcotics
    • Have a head injury
    • Take certain medications (see Tramadol and Seizures for more information).
  • ConZip should not be prescribed to people who have suicidal tendencies. This medication can be lethal in the case of an overdose, especially if combined with alcohol.
  • ConZip has a significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse (see Tramadol Abuse). Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with ConZip, please seek help from your healthcare provider.
  • This medicine can cause a dangerous group of symptoms known as serotonin syndrome. This most commonly occurs when ConZip is combined with certain other medications (see Tramadol and Serotonin Syndrome for more information).
  • ConZip can cause slow and irregular breathing. In severe situations, this may lead to life-threatening complications. It could be especially dangerous in people with lung problems.
  • The medication can cause problems in people with head injuries or high intracranial pressure. ConZip should only be used with extreme caution in these circumstances.
  • ConZip can interfere with the diagnosis of many conditions that cause severe abdominal (stomach) pain.
  • This drug can cause dizziness and drowsiness, which may increase the risk of falls in elderly people.
  • Do not drive or operate heavy machinery until you know how ConZip affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.
  • ConZip is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Tramadol and Pregnancy).
  • ConZip passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Tramadol and Breastfeeding).
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