How Does It Work?ConZip capsules are specially designed to release the medication continuously over a 24-hour period. The active ingredient, tramadol, is classified as a "centrally acting opioid analgesic." This means that it works in the central nervous system (the brain and spinal cord), acts much like morphine in the body, and relieves pain. ConZip binds to certain opioid receptors in the body known as μ ("mu") receptors.
ConZip also works in a similar way as some antidepressant medications by inhibiting the reuptake of certain brain chemicals (serotonin and norepinephrine). Serotonin and norepinephrine are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release serotonin or norepinephrine. The serotonin or norepinephrine enters the gap between the first nerve cell and the one next to it. When enough serotonin or norepinephrine reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any serotonin or norepinephrine that remains in the gap between cells. This is called "reuptake."