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How Does ConZip Work?

ConZip capsules are specially designed to release the medication continuously over a 24-hour period. This medication contains tramadol, a drug that is classified as a "centrally acting opioid analgesic." This means that it works in the central nervous system (the brain and spinal cord), acts much like morphine in the body, and relieves pain. Much like morphine, ConZip binds to certain opioid receptors in the body known as μ ("mu") receptors.
ConZip also works in a similar way as some antidepressant medications by inhibiting the reuptake of certain brain chemicals (serotonin and norepinephrine). Serotonin and norepinephrine are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release serotonin or norepinephrine. The serotonin or norepinephrine enters the gap between the first nerve cell and the one next to it. When enough serotonin or norepinephrine reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any serotonin or norepinephrine that remains in the gap between cells. This is called "reuptake."

When and How to Take It

Some general considerations to keep in mind during treatment with ConZip include the following:
  • ConZip comes in the form of an extended-release capsule. It is usually taken once a day.
  • This medicine can be taken with or without food. If it seems to bother your stomach, try taking it with a little food.
  • Breaking, dissolving, or crushing ConZip capsules can be very dangerous, as this will cause too much of the medication to be released too quickly.
  • For the medication to work properly, it must be taken as prescribed. Do not increase your dose without your healthcare provider's approval. Also, do not suddenly stop taking ConZip, especially if you have taken it regularly for more than several weeks (see Tramadol Withdrawal).
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ConZip Drug Information

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