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Clinoril Precautions and Warnings

Specific Clinoril Precautions and Warnings

Warnings and precautions with Clinoril to be aware of prior to starting the drug include the following:
  • Clinoril can interact with certain medications (see Clinoril Drug Interactions).
  • All NSAIDs (nonsteroidal anti-inflammatory drugs), including Clinoril, have been reported to cause cardiovascular events, such as a heart attack or stroke, which can result in loss of life. People with cardiovascular disease or who have risk factors for the condition appear to be at greater risk. To decrease the chances of developing these problems, you should take the smallest effective dose for the shortest period of time. Call 911 if you notice things such as:
    • Chest pain
    • Shortness of breath
    • Weakness
    • Slurring of speech.
  • All NSAIDs, including Clinoril, may cause high blood pressure or make it worse. Therefore, Clinoril should be used with caution in people with known high blood pressure.
  • All NSAIDs, including Clinoril, may cause congestive heart failure or swelling. Contact your healthcare provider if you notice unexplained weight gain or swelling. Also, Clinoril should be used with caution in people with heart failure.
  • All NSAIDs, including Clinoril, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines (called perforations). These problems can lead to serious complications or even loss of life. Thus, extreme caution should be used if Clinoril is prescribed for people with a history of ulcers or gastrointestinal bleeding. To decrease the chances of developing these problems, you should take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
    • Stomach pain
    • Indigestion
    • Black, tarry stools
    • Vomiting blood.
  • Kidney damage can happen in people taking NSAIDs, including Clinoril. It is more common in people with kidney disease, heart failure, liver problems, those taking a diuretic or ACE inhibitor, and the elderly.
  • Liver damage can occur in people who are taking Clinoril. Contact your healthcare provider immediately if you notice:
    • Nausea
    • Tiredness
    • Lethargy
    • Itchy or yellowing skin
    • Abdominal pain
    • Flu-like symptoms.
  • NSAIDs, including Clinoril, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice:
    • Hives
    • Unexplained rash
    • Difficulty breathing
    • Swelling of the face and throat.
  • In rare cases, people taking Clinoril can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the Clinoril and call your healthcare provider right away.
  • Cases of renal stones have been reported rarely in people taking Clinoril. Therefore, you should stay well hydrated while taking Clinoril to avoid this complication.
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting Clinoril. Alcohol can affect the way the liver works, indirectly affecting the way Clinoril works.
  • NSAIDS have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that checks your liver function before starting Clinoril and then again 12 weeks after treatment has started.
  • Clinoril has been known to cause anemia. Therefore, if you are taking Clinoril for an extended amount of time and show signs of anemia, talk to your healthcare provider.
  • Problems with vision have been reported in people taking Clinoril. If you notice any changes in your vision, such as blurry vision or changes in color vision, contact your healthcare provider.
  • You should not take Clinoril with any other NSAIDs, as this may increase your risk for any of the problems discussed in this article. Many NSAIDs are available without a prescription, so make sure to read labels carefully. Examples of NSAIDs include:
  • Clinoril is a pregnancy Category C medicine, meaning that it could potentially cause harm to your unborn child. If you are pregnant, you should only take Clinoril if the benefit outweighs the possible risk to your unborn child. Clinoril is not recommended for women in the third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking Clinoril, contact your healthcare provider immediately (see Clinoril and Pregnancy).
  • If you are nursing, it is recommended that you do not take Clinoril. If you are nursing and taking Clinoril, ask your healthcare provider whether to stop nursing or discontinue the medicine.
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