Drug Interactions With Children's Acetaminophen

Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
Carbamazepine can affect the way the body handles children's acetaminophen, making both drugs more toxic and less effective. Talk to your child's healthcare provider about using children's acetaminophen in children who take carbamazepine.
 
Codeine and Acetaminophen (Capital and Codeine, Phenco-Care, Tylagesic, Acetaminophen No. 3, Acetaminophen No. 4)
In general, you should avoid giving your child children's acetaminophen if he or she is taking codeine and acetaminophen products, as you may give your child too much acetaminophen (the active ingredient of children's acetaminophen).
 
Isoniazid (Nydrazid)
Taking children's acetaminophen and isoniazid together may increase the risk of liver damage. Talk to your child's healthcare provider before using these medications together.
 
Phenobarbital (Luminal)
Phenobarbital can affect the way your child's body handles children's acetaminophen, making it both less effective and more toxic. Talk to your child's healthcare provider about using children's acetaminophen if your child is taking phenobarbital.
 
Several Cough, Cold, Flu, and Allergy Products
Many of these types of medications contain acetaminophen, the active ingredient of children's acetaminophen. Only use one of these products at a time, so that you do not inadvertently give your child too much acetaminophen.
 
Warfarin (Coumadin, Jantoven)
Taking warfarin with children's acetaminophen may increase the risk of bleeding. However, this risk is much less than for other non-prescription pain relievers (such as aspirin). Talk with your child's healthcare provider about the best ways to treat pain and fevers in a child who is taking warfarin.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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