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Drug Interactions With Celecoxib

An increased risk of stomach ulcers, increased drug levels in the blood, and decreased effectiveness of certain medications can all occur when celecoxib is taken with other medications. Celecoxib may interact with aspirin, fluconazole, and lithium. If you are experiencing celecoxib drug interactions, your healthcare provider may adjust your dosages or monitor you more closely.

Celecoxib (Celebrex)

Interactions With Celecoxib: An Overview

Celecoxib (Celebrex^®) can potentially interact with a number of medications. Medicines that can cause celecoxib drug interactions include:

Angiotensin converting enzyme (ACE) inhibitors:
- Benazepril (Lotensin^®), benazepril-hydrochlorothiazide (Lotensin^® HCT), or benazepril-amlodipine (Lotrel^®)
- Captopril (Capoten^®) or captopril-hydrochlorothiazide (Capozide^®)
- Enalapril (Vasotec^®), enalapril-hydrochlorothiazide (Vaseretic^®), or enalapril-felodipine (Lexxel^®)
- Fosinopril (Monopril^®) or fosinopril-hydrochlorothiazide (Monopril-HCT^®)
- Lisinopril (Prinivil^®, Zestril^®) or lisinopril-hydrochlorothiazide (Prinzide^®, Zestoretic^®)
- Quinapril (Accupril^®) or quinapril-hydrochlorothiazide (Accuretic^®, Quinaretic^™)
- Ramipril (Altace^®)

Angiotensin II receptor blockers (ARBs), such as:
- Candesartan (Atacand^®) or candesartan-hydrochlorothiazide (Atacand HCT^®)
- Eposartan (Teveten^®) or eposartan-hydrochlorothiazide (Teveten^® HCT)
- Irbesartan (Avapro^®) or irbesartan-hydrochlorothiazide (Avalide^®)
- Losartan (Cozaar^®) or losartan-hydrochlorothiazide (Hyzaar^®)
- Olmesartan (Benicar^®), olmesartan-hydrochlorothiazide (Benicar HCT^®), or amlodipine and olmesartan (AZOR^™)
- Telmisartan (Micardis^®) or telmisartan-hydrochlorothiazide (Micardis^® HCT)
- Valsartan (Diovan^®) or valsartan-hydrochlorothiazide (Diovan HCT^®)

Aspirin
Diuretics, such as:
- Bumetanide (Bumex^®)
- Chlorothiazide (Diuril^®)
- Chlorthalidone (Thalitone^®)
- Ethacrynic acid (Edecrin^®)
- Furosemide (Lasix^®)
- Hydrochlorothiazide (Esidrix^®, HydroDIURIL^®, Microzide^®, Oretic^®)
- Metolazone (Zaroxolyn^®)
- Torsemide (Demadex^®)
- Triamterene (Dyrenium^®) or triamterene/HCTZ (Dyazide^®, Maxzide^®)
- Fluconazole (Diflucan^®)
- Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)

Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Diclofenac (Cataflam^®, Voltaren^®)
- Etodolac (Lodine^®)
- Ibuprofen (Motrin^®, Advil^®)
- Indomethacin (Indocin^®)
- Ketoprofen (Orudis^®)
- Ketorolac (Toradol^®)
- Meloxicam (Mobic^®)
- Nabumetone (Relafen^®)
- Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
- Oxaprozin (Daypro^®)

Warfarin (Coumadin^®, Jantoven^®).

(Drug Interactions With Celecoxib Continued: Page 2)

List of references (click here)

Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD

Last reviewed by: Kristi Monson, PharmD;

Other Articles in This eMedTV Presentation

Side Effects of Celecoxib

Celecoxib Dosing

Precautions and Warnings for Celecoxib

Referring Pages

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