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Drug Interactions With Celecoxib

Digoxin
Celecoxib may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping celecoxib.
 
Diuretics
Combining celecoxib with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Fluconazole
Taking fluconazole and celecoxib together may increase the level of celecoxib in your blood, possibly increasing the risk of side effects. Your healthcare provider may choose to start you on a lower celecoxib dosage to avoid this interaction.
 
Lithium
Taking celecoxib and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining celecoxib with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine celecoxib with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Celecoxib may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of celecoxib in the blood, which increases the risk of celecoxib side effects. Check with your healthcare provider before taking these medications together.
What Your Pharmacist Wishes You Knew About Chronic Pain Medications

Celecoxib (Celebrex)

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