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Drug Interactions With Celecoxib

More Information on Drug Interactions With Celecoxib

The following sections explain in detail how the drugs listed above can have a negative effect if taken with celecoxib.
ACE Inhibitors
When ACE inhibitors and celecoxib are taken together, the effectiveness of the ACE inhibitor may be reduced. Your healthcare provider may adjust your dose of the ACE inhibitor or may suggest an alternative to celecoxib in some situations.
Angiotensin II Receptor Blockers (ARBs)
Celecoxib may make ARBs less effective. Check with your healthcare provider before combining these two medications.
Low-dose aspirin (81 mg) and celecoxib can be used together; however, studies have indicated that the risk of stomach ulcers is higher when these medicines are combined. Talk to your healthcare provider about using aspirin and celecoxib together in your particular situation.
Beta Blockers
Combining celecoxib with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
Bile Acid Sequestrants
Bile acid sequestrants can bind to celecoxib in the digestive tract and delay its absorption into the body. To avoid this drug interaction, celecoxib should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
Using corticosteroids with celecoxib can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
Celecoxib may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
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