Drug Interactions With Celecoxib (Cont.)

 
Fluconazole
Taking fluconazole and celecoxib together may cause your body to metabolize the celecoxib differently than intended. Your healthcare provider may choose to start you on a lower dose of celecoxib if this is the case.
 
Furosemide
Taking furosemide and celecoxib together may decrease the effectiveness of furosemide. Your healthcare provider may adjust your doses as needed if this interaction occurs.
 
Thiazide Diuretics
Taking both a thiazide diuretic and celecoxib may decrease the effectiveness of the thiazide. Your healthcare provider may adjust your doses of these medications to prevent this interaction from occurring.
 
Lithium
Taking lithium and celecoxib together may cause an increase in lithium levels. If this occurs, your healthcare provider may choose to monitor your lithium levels more closely when starting or discontinuing celecoxib.
 
Warfarin
If you are taking celecoxib and warfarin together, your body may metabolize the warfarin differently than intended. When starting celecoxib therapy or changing your celecoxib dosage, your healthcare provider may choose to monitor your INR (international normalized ratio) more closely and make any necessary dosing adjustments.
 

Final Thoughts on Drug Interactions With Celecoxib

It is possible that not all of the drug interactions with celecoxib were discussed in this article. Therefore, it is important to talk with your healthcare provider about any drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;