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How Does the Medication Work?

Celecoxib works by blocking a particular enzyme (COX-2) that plays a role in pain and inflammation. Unlike other NSAIDs (such as ibuprofen and naproxen) that target both the COX-1 and COX-2 enzymes, this medication only targets the COX-2 enzyme. The COX-1 enzyme plays an important role in protecting the lining of the stomach.

When and How Do I Take Celecoxib?

General considerations for when and how to take this medication include the following:
  • Celecoxib comes in capsule form. It is taken either once or twice a day, depending on the condition being treated. You should take your dose with a glass of water, with or without food. People taking 400 mg twice daily should take this dose with food.
  • It does not matter if your dose is taken in the morning or at night. However, you should take celecoxib at the same time each day to maintain an even level in your blood.
  • Do not break, chew, or crush the capsules. If necessary, you may open the capsules and sprinkle the contents on a spoonful of cool or room-temperature applesauce. This should be swallowed immediately and followed with water, although the medication is stable in the applesauce for up to six hours under refrigeration.
  • For celecoxib to work properly, you have to take it as prescribed. The medication will not work if you stop taking it.
  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the risk of serious side effects.

Dosing Information

The dose of celecoxib your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you are currently taking
  • Your weight.
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
(Click Celecoxib Dosing for more information.)
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Celecoxib (Celebrex)

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