Celecoxib (Cont.)

How Does Celecoxib Work?

Celecoxib works by blocking a particular enzyme (COX-2) that plays a role in pain and inflammation. Unlike other NSAIDs (such as ibuprofen and naproxen) that target both the COX-1 and COX-2 enzymes, celecoxib only targets the COX-2 enzyme. The COX-1 enzyme plays an important role in protecting the lining of the stomach.
 

When and How Do I Take Celecoxib?

General considerations for when and how to take celecoxib include the following:
 
  • Celecoxib comes in capsule form. It is taken either once or twice a day, depending on the condition being treated. It is recommended that you take your celecoxib dose with a glass of water, with or without food. For people taking 400 mg of celecoxib, it should be taken with food.
     
  • It does not matter if celecoxib is taken in the morning or at night. However, you should take celecoxib at the same time each day to maintain an even level of the medication in your blood.
     
  • Do not break, chew, or crush the celecoxib capsules.
     
  • For celecoxib to work properly, you have to take it as prescribed. Celecoxib will not work if you stop taking it.
     
  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the risk of serious side effects.
     

Dosing Information for Celecoxib

The dose of celecoxib recommended by your healthcare provider will vary depending on a number of factors, including:
 
  • The medical condition you are being treated for
  • Other medical conditions you may have
  • Other medications you are currently taking
  • Your weight.
     
As is always the case, do not adjust your dose unless specifically instructed by your healthcare provider to do so.
 
(Click Celecoxib Dosing for more information.)
 
(Celecoxib Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;