Butrans Drug Interactions

Butrans may react negatively with alcohol, benzodiazepines, sleep medications, and various other drugs. Even though Butrans comes in the form of a skin patch, some of the medication is absorbed into the bloodstream and can react with certain drugs. Interactions with Butrans patches may lead to various side effects or increase the risk for serious complications, such as breathing problems and extreme drowsiness.

An Overview of Interactions With Butrans

Butrans® (buprenorphine patch) is a patch that is applied to the skin. It can potentially react with several other medications, since some of the active ingredient is absorbed into the bloodstream.
 
Some of the drugs that may interact with Butrans include but are not limited to:
 
  • Alcohol
  • Benzodiazepines, such as:
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Medications that cause drowsiness, such as:
 
 
  • Medications that cause a change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications)
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
Butrans Drug Interactions Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD
 
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