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What Is Anakinra Used For?

Using Anakinra for NOMID

Cryopyrin-associated periodic syndromes (CAPS) are a group of rare hereditary conditions, including:
 
  • Familial cold autoinflammatory syndrome (FCAS)
  • Muckle-Wells syndrome (MWS)
  • Neonatal-onset multisystem inflammatory disease (NOMID).
 
NOMID is the most severe form of CAPS. Symptoms usually begin at birth, are progressive, and can lead to severe complications, such as hearing loss, vision loss, joint damage, and death. Studies suggest that Kineret actually halts the organ damage caused by NOMID.
 
Anakinra is approved to treat NOMID in both children and adults.
 

How Does Anakinra Work?

People with rheumatoid arthritis often have high levels of a certain protein called interleukin-1 (IL-1) in their joints. IL-1 causes inflammation, cartilage damage, and bone erosion. Anakinra is a synthetic form of a different naturally occurring protein in the body that inhibits the effects of IL-1. By binding to IL-1, it can help reduce the symptoms of rheumatoid arthritis, along with the physical damage to the joints.
 
Anakinra works to treat NOMID in the same manner (by inhibiting the inflammatory IL-1 protein). 
 

Is Anakinra Used in Children?

Anakinra is not approved for treating rheumatoid arthritis in children (often known as juvenile rheumatoid arthritis). It is approved for treating NOMID in children, even babies. Talk to your healthcare provider about the benefits and risks of using the drug in children.
 

Off-Label Uses for Anakinra

On occasion, your healthcare provider may recommend anakinra for treating something other than rheumatoid arthritis. Currently, off-label uses of anakinra include treatment of the following conditions:
 
  • Familial cold autoinflammatory syndrome (FCAS)
  • Muckle-Wells syndrome (MWS)
  • Uveitis (an eye condition).
 
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