Drug Interactions With Acetaminophen

Some of the medications that may cause drug interactions with acetaminophen include warfarin, carbamazepine, cholestyramine, and barbiturates. These interactions may affect the way your body handles acetaminophen, which can make both drugs less effective and more toxic. If you take other products that contain acetaminophen, drug interactions may also occur because you should not take more than 4000 mg total of the drug per day.

 

Drug Interactions With Acetaminophen: An Overview

Acetaminophen (Tylenol®) can potentially interact with other medications. Some of these medicines that may lead to acetaminophen drug interactions include:
 
  • Alcohol
  • Barbiturates, such as:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
o Anexia®
o Dolorex Forte®
o Hycet™
o Liquicet™
o Lorcet® and Lorcet® Plus
o Lortab®
o Margesic-H™
o Norco®
o Vicodin®, Vicodin® ES, and Vicodin® HP
o Xodol®
o Zydone®
  • Isoniazid (Nydrazid®)
  • Many non-prescription cough, cold, and allergy products
  • Many non-prescription menstrual medications (such as Midol®)
  • Oxycodone and acetaminophen (Endocet®, Magnacet™, Narvox®, Percocet®, Perloxx®, Roxicet®, Tylox®)
  • Propoxyphene and acetaminophen (Balacet 325™, Darvocet®)
  • Tramadol and acetaminophen (Ultracet®)
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Acetaminophen Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;