Drug Interactions With Acetaminophen

Some of the medications that may cause acetaminophen drug interactions include warfarin, carbamazepine, cholestyramine, and barbiturates. These interactions may affect the way your body handles acetaminophen, which can make both drugs less effective and more toxic. If you take other products that contain acetaminophen, you should not take more than 4000 mg total of the drug per day.

Acetaminophen Drug Information

(In November 2010, the United States Food and Drug Administration approved an intravenous form of acetaminophen. For information on this product, see Ofirmev.)

Acetaminophen Interactions: An Overview

Acetaminophen (Tylenol^®) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with acetaminophen include:

Alcohol
Barbiturates, such as:

Amobarbital (Amytal^®)
Butalbital (Fioricet^®, Fiorinal^®)
Pentobarbital (Nembutal^®)
Phenobarbital (Luminal^®)
Secobarbital (Seconal^®)

Carbamazepine (Carbatrol^®, Epitol™, Equetro^®, Tegretol^®)
Cholestyramine (Prevalite^®, Questran^®)
Codeine and acetaminophen products (Capital^® and Codeine, Phenco-Care™, Tylagesic™, Acetaminophen No. 3, Acetaminophen No. 4)
Hydrocodone and acetaminophen products, such as:

Anexia^®
Co-Gesic^®
Dolorex Forte^®
Hycet™
Liquicet™
Lorcet^® and Lorcet^® Plus
Lortab^®
Margesic-H™
Maxidone™
Norco^®
Stagesic^®
Vicodin^®, Vicodin^® ES, and Vicodin^® HP
Xodol^®
Zydone^®

Isoniazid (Nydrazid^®)
Many non-prescription cough, cold, and allergy products
Many non-prescription menstrual medications (such as Midol^®)
Oxycodone and acetaminophen products (Endocet^®, Magnacet™, Narvox^®, Percocet^®, Perloxx^®, Roxicet^®, Tylox^®)
Propoxyphene and acetaminophen products (Balacet 325™, Darvocet^®)
Tramadol and acetaminophen products (Ultracet^®)
Warfarin (Coumadin^®, Jantoven^®).

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