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Drug Interactions With Acetaminophen

Isoniazid (Nydrazid)
Taking acetaminophen with isoniazid may increase your risk of liver damage. Talk to your healthcare provider before using these medications together.
 
Many Cough, Cold, and Allergy Products
Many of these types of medications contain acetaminophen. Be very careful to monitor the amount of acetaminophen you take each day, and do not exceed 4000 mg per day (for adults).
 
Many Menstrual Medications
Many of these types of medications contain acetaminophen. Be very careful to monitor the amount of acetaminophen you take each day, and do not exceed 4000 mg per day (for adults).
 
Oxycodone and Acetaminophen Products
In general, you should avoid acetaminophen if you are taking oxycodone and acetaminophen products, as you may inadvertently take too much acetaminophen. Be very careful to monitor the amount of acetaminophen you take each day, and do not exceed 4000 mg per day (for adults).
 
Propoxyphene and Acetaminophen Products (Balacet 325, Darvocet)
In general, you should avoid acetaminophen if you are taking propoxyphene and acetaminophen products, as you may inadvertently take too much acetaminophen. Be very careful to monitor the amount of acetaminophen you take each day, and do not exceed 4000 mg per day (for adults).
 
Tramadol and Acetaminophen Products (Ultracet)
In general, you should avoid acetaminophen if you are taking tramadol and acetaminophen products, as you may inadvertently take too much acetaminophen. Be very careful to monitor the amount of acetaminophen you take each day, and do not exceed 4000 mg per day (for adults).
 
Warfarin (Coumadin, Jantoven)
Taking warfarin with acetaminophen may increase your risk of bleeding. However, this risk is much less common than for other non-prescription pain relievers (such as aspirin). If you suddenly and drastically change your acetaminophen dosage, contact your healthcare provider, as you may need to be monitored more closely.
 
What Your Pharmacist Wishes You Knew About Chronic Pain Medications

Acetaminophen Drug Information

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